12 results
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• IgA vasculitis ... • Vasculitis ... erythematosus ( ... #rheumatology # ... vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... Vasculitis: + MPO-ANCA ... differential #diagnosis ... #rheumatology # ... classification
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... : Vasculitis: ... • Ig A vasculitis ... Diagnosis #hematology ... #rheumatology #
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm ... #rheumatology
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Vasculitis Vasculitis ... small vessels - ANCA-associated ... - systemic lupus ... erythematosus ... #Diagnosis #Rheumatology
Vascular Skin Lesions - Differential Diagnosis Algorithm
 - Petechiae < 0.2 cm diameter
 - Purpura 0.2
Diagnosis Algorithm ... • Acquired - Vasculitis ... #Vascular #Vasculitis ... #SkinRash #dermatology ... Diagnosis #Algorithm
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... Nodosa (PAN), ANCA ... associated vasculitis ... erythematosus ( ... #Diagnosis #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Pauci-immune vasculitis ... Diagnosis: Vasculitis ... Granulomatous vasculitis ... • Necrotising vasculitis ... #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... tract, and often causes ... + MPO) Cryoglobulinemic ... Diagnosis #Rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... #Hematology #Monoclonal ... #Differential # ... Diagnosis #Oncology