9 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
cold agglutin disease ... Mycoplasma pneumoniae infection ... e.g. sickle cell disease ... spherocytosis) • Infections ... diagnosis #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... SLE) - Viral infections ... APLS • Acute Infectious ... : Schamberg Disease ... #Diagnosis #hematology
Right-Sided Heart Failure - Differential Diagnosis Algorithm
Cardiac Causes - Rule out Left-Sided Heart Failure (Most Common):
Obstructive Pulmonary Disease ... • Diffuse Lung Disease ... • Chronic Lung Infection ... Veno-Occlusive Disease ... #Cardiology #Differential
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Chronic lung disease ... • Infectious ... Granulomatous disease ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
- Due to Viral infection ... Polyclonal - Viral Infection ... Diagnosis: • hemolytic ... Check For: • Infections ... #hematology #diagnosis
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
but elevated as disease ... pregnancy, Cardiac diseases ... fungal, viral infections ... , IgG4 related disease ... #workup #hepatology
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
polymicrobial infection ... • Periodontal disease ... disease: Pleuritic ... in early disease ... #causes #management
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
rheumatic diseases ... to exclude are infections ... Recurrent middle ear infections ... , recent viral infection ... #Diagnosis #Rheumatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... • Autoimmune disorders ... (NSHL) - (most common ... number of sites of disease ... classification #hematology