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hematology allergy causes definitions extravascular hemolytic intravascular nonpalpable palpable pathophysiology platelets purpura table thrombocytosis
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
anemia, Penicillin-induced ... • Ex: Systemic Lupus ... #Reactions #Types ... #Classification ... #Diagnosis #Definitions
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
or during hemolytic ... , and systemic lupus ... - Contact dermatitis ... #Types #Classification ... #Diagnosis #Reactions
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... , deficiency anemia ... #Diagnosis #Algorithm ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... Pigmented Purpuric Dermatosis ... fever • Drug reactions ... #Diagnosis #hematology
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