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hematology allergy hypersensitivity causes definitions dermatology erythematosus extravascular hemolytic intravascular nonpalpable palpable pathophysiology platelets purpura sle systemic table thrombocytosis
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
anemia, Penicillin-induced ... • Ex: Systemic Lupus ... #Allergic #Reactions ... #Types #Classification ... #Diagnosis #Definitions
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
or during hemolytic ... , and systemic lupus ... - Contact dermatitis ... #Classification ... #Diagnosis #Reactions
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... blood loss, Acute hemolysis ... , deficiency anemia ... post-splenectomy, Exercise, Allergic ... #Diagnosis #Algorithm
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... Pigmented Purpuric Dermatosis ... fever • Drug reactions ... #Diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... permanent alopecia Differential ... Kikuchi disease • Type-I ... lymphopenia, low PLT • Anemia ... #Rheumatology
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