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differential sle systemic champs criteria cryoglobulins eularacr glomerulonephritis hypocomplementemia mnemonic monoclonal oncology progressive rapidly rpgn vasculitides
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Mnemonic C - Cryoglobulinemia ... S - Systemic Lupus ... Erythematosus ( ... total 50, renal ... #differential #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
factor level • Low ... serum C4 complement ... erythematosus ( ... #types #classification ... #rheumatology #
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Erythematosus ... pericarditis • Hematologic ... hemolysis • Renal ... anticoagulant • Complement ... #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... GN, Lupus Nephritis ... , Cryoglobulinemia ... #differential #diagnosis ... #algorithm #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
complements and ... Skin Disease Classification ... Kikuchi disease • Type-I ... APLA/LAC: • Renal ... #Diagnosis #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Neutrophilic dermatosis ... to cold IgG • Lupus ... vascular beds-renal ... #Hematology #Monoclonal ... #Differential #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... against MPO • Complement ... (Low levels mixed ... #rheumatology # ... classification
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