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diagnosis differential sle systemic ana anca antibody antineutrophil antinuclear champs complement cryoglobulins glomerulonephritis hypocomplementemia low management mnemonic monoclonal nephritis nephrology
Renal Involvement in Systemic Lupus Erythematosus Dr. Laurent ARNAUD @Lupusreference #Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Renal Involvement ... Erythematosus ... #diseases #SLE ... nephrology #nephritis #classification ... #types #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... (e.g. systemic lupus ... erythematosus ( ... #classification ... #rheumatology #
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Chain deposition disease ... S - Systemic Lupus ... Erythematosus ( ... total 50, renal ... #differential #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... Non-autoimmune rheumatologic ... • Type-I Interferonopathies ... APLA/LAC: • Renal ... #Diagnosis #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... erythematosus ... ANCA-Associated Vasculitis ... vasculitis - MPO ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... erythematosus, ... C-ANCA) pattern: antibodies ... differential #diagnosis #rheumatology ... #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Post-strep GN, Lupus ... Nephritis, Cryoglobulinemia ... Purpura Anti-GBM antibodies ... involvement: Anti-GBM Disease ... #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... • Neutrophilic dermatosis ... to cold IgG • Lupus ... vascular beds-renal ... Paraproteinemias #Hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
cirrhosis: 3%-20% Renal ... I) renal tubular ... Nephrogenic DI Hematologic ... : • 7%, Cryoglobulinemia ... Sjogrens #Syndrome #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... ischemia • Skin: Erythematous ... / ANCA + MPO) Cryoglobulinemic ... - interstitial keratitis ... Differential #Diagnosis #Rheumatology
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