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2021 ACR/VF Guidelines for Management of Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)

#Granulomatosis #Polyangiitis #GPA
(GPA) and Microscopic ... Polyangiitis (MPA ... #GPA #Microscopic ... MPA #ACR2021 #Management ... algorithm #vasculitis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
(C-ANCA): GPA > ... >> MPA > eGPA • ... MPO-ANCA (P-ANCA ... ): eGPA, MPA >>> ... GPA Stanford Internal
Vasculitis Management - ACR/VF 2021 Guidelines for Treatment & Management
 • Giant Cell Arteritis (GCA)
 •
Vasculitis Management ... (GPA), Microscopic ... Polyangiitis (MPA ... #ACR2021 #Guidelines ... #algorithm #rheumatology
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021
(GPA) and Microscopic ... #GPA #Microscopic ... MPA #ANCA #Vasculitis ... #ACR2021 #Guidelines ... #algorithm #rheumatology
Eosinophilic Granulomatosis with Polyangiitis (EGPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021 Guidelines
 • Active
(EGPA) - ANCA Vasculitis ... Management Algorithm ... #ANCA #Vasculitis ... #ACR2021 #Guidelines ... #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Polyangiitis: ... capillaritis • EGPA ... > PR3 60% • GPA ... Vasculitis: + MPO-ANCA ... (Dx: GPA, EGPA,
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
myeloperoxidase (MPO-ANCA ... )): Microscopic ... progressive) EGPA ... > PR3 60/ GPA ... Differential #Diagnosis #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... polyangiitis ... (e.g. systemic lupus ... #rheumatology #