9 results
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
complexes • Ex: Systemic ... Lupus Erythematosus ... Syndrome, Contact Dermatitis ... Reactions #Types #Classification ... #Diagnosis #Definitions
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
- Differential Diagnosis ... Algorithm Vesicles ... • Bullous systemic ... lupus erythematous ... Vesiculobullous #SkinRash
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Lupus Erythematosus ... Disease, PRES Pathophysiology ... #Lupus #Erythematosus ... CNS #neurology #rheumatology ... #management #treatment
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of ... vasculitis - hypersensitivity ... lupus erythematosus ... #Rheumatology # ... Diagnosis
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
lupus erythematosus ... - Contact dermatitis ... #Types #Classification ... #Pathophysiology ... #Allergy #Diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lupus erythematosus ... lupus erythematosus ... • Drug-induced hypersensitivity ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... vasculitis • Hypersensitivity ... lupus erythematosus ... #types #classification ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
inflammation Others: • Lupus ... ischemia - Skin: erythematous ... lupus erythematosus ... #rheumatology # ... classification
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
disorders, including systemic ... lupus erythematosus ... cell lymphoma Pathophysiology ... in LNs and the systemic ... #management #rheumatology