6 results
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... : • Clinical triad ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
Infectious manifestations ... Neutrophilic dermatosis ... (dermatomyositis ... #differential # ... #oncology #clinical
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
associated with autoimmune ... malignancies, vasculitis ... Malignancy • Infections ... • Negative causes ... Antiphospholipid syndrome
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Agglutinin Syndrome ... Clinical Presentation ... presentation) • Cutaneous ... younger pts) Differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... Differential ... Still disease, dermatomyositis ... fibromyalgia) • Infections
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... to exclude are infections ... C-ANCA) pattern: antibodies ... Serologies for Cryoglobulins ... differential #diagnosis