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rheumatology classification dermatology hematology agglutinin algorithm anemia cryofibrinogenemia cryoglobulinemia cutaneous disease erythematosus hemolytic manifestations myelodysplastic oncology petechiae petechial rash sle
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... Cause Organ Damage ... : • Clinical triad ... (e.g. systemic lupus
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
Infectious manifestations ... Neutrophilic dermatosis ... (dermatomyositis ... #differential # ... #oncology #clinical
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Palpable Rash: - Autoimmune ... Vasculitis (lupus ... immunoglobulins & cryoglobulins ... • Skin biopsy ... #physicalexam
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Agglutinin Syndrome ... , autoimmune disorder ... Clinical Presentation ... younger pts) Differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... to exclude are infections ... C-ANCA) pattern: antibodies ... Serologies for Cryoglobulins ... differential #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... Differential ... Still disease, dermatomyositis ... fibromyalgia) • Infections
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
associated with autoimmune ... malignancies, vasculitis ... Malignancy • Infections ... • Negative causes ... Antiphospholipid syndrome
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