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Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... Cause Organ Damage ... : • Clinical triad ... (e.g. systemic lupus
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
Infectious manifestations ... Neutrophilic dermatosis ... , SLE,...) 4 ... leukocytoclastic vasculitis ... #differential #
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Necrotizing, pauci-immune ... tract, and often causes ... to exclude are infections ... , and SLE) • Urinalysis ... Serologies for Cryoglobulins
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... Still disease, dermatomyositis ... fibromyalgia) • Infections ... context of primary immune
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... diseases, such as SLE ... tract, and often causes ... - interstitial keratitis