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diagnosis rheumatology dermatology hematology oncology algorithm causes cryoglobulins cutaneous dermatologic erythematosus gpa granulomatosis hand lcv leukocytoclastic manifestations monoclonal myelodysplastic nephrology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... • Infections: ... HCV infection, ... (e.g. systemic lupus ... diagnosis #types #classification
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
foliaceus - Infectious ... • Contact dermatitis ... herpetiformis ... Bullous systemic lupus ... Vesiculobullous #SkinRash
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... Behcet disease, Cryoglobulinemia ... Complex: Systemic lupus ... allopurinol), Infection ... #differential #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... ANCA +MPO) • Cryoglobulinemic ... such as systemic lupus ... to exclude are infections ... #rheumatology #classification
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... SLE) - Viral infections ... Kasabach-Merritt syndrome ... Pigmented Purpuric Dermatosis ... /HSP • Cryoglobulinemia
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Neutrophilic dermatosis ... (Cryoglobulinemic ... to cold IgG • Lupus ... Subcorneal pustular dermatosis ... Hematology #Monoclonal #Differential
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
Infectious manifestations ... Neutrophilic dermatosis ... leukocytoclastic vasculitis ... #differential # ... dermatology #oncology #clinical
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... to exclude are infections ... / ANCA + MPO) Cryoglobulinemic ... - interstitial keratitis
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... reticularis Differential ... purpura • Mixed cryoglobulinemia ... • Goodpasture syndrome ... cell arteritis Infections
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Skin Disease Classification ... permanent alopecia Differential ... fibromyalgia) • Infections ... Clinical Features
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