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diagnosis aortitis cold cryoglobulinemia cryoglobulins dermatologic dermatology erythematosus gap gca giantcell globulin granulomatosis hemolytic polyangiitis polychondritis protein proteingap rash relapsing
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Aortitis - Differential ... Syndrome, Relapsing ... (RA), Systemic lupus ... MD @MithuRheu and ... #Diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... • Autoimmune diseases ... Types II and III ... #classification ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
> PR3 60% • GPA ... often causes arthritis ... to exclude are infections ... #rheumatology # ... classification
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Disease 3 Types ... Cryoglobulins (Vasculitic ... Syndrome (CAS): ... Clinical Presentation ... #anemia #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... • Goodpasture syndrome ... • Giant cell arteritis ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... fibromyalgia) • Infections ... • Type-I Interferonopathies ... Erythematosus #Diagnosis #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... MPO > PR3 60/ GPA ... often causes arthritis ... - interstitial keratitis ... #Rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
arteritis (GCA) ... Diagnosis = clinical ... vs infection vs ... variably: On one hand ... them, but urgent rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... (RA, Temporal arteritis ... gastric tumors • Hematology ... Comment on type ... #diagnosis #hematology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
• Infections ... • Lymphoma • GPA ... Antibodies to type ... Polychondritis #rheumatology ... #diagnosis #management
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