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diagnosis causes hematology bruising cryoglobulinemia cryoglobulins erythematosus extravascular hemolysis high hyperkalemia hypertension intravascular monoclonal oncology pancytopenia paraproteinemias pediatrics peds phtn
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease ... Agglutinin Syndrome ... anemia • Cold ... #agglutinin #disease ... #hemolytic #anemia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... usually IgG) (e.g. lupus ... agglutin disease ... Extravascular #Causes #differential ... #anemia
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... : • Systemic lupus ... Antibody-mediated hemolysis ... deficiency Infections
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... • Coombs (-) hemolytic ... anemia due to cold ... IgG • Lupus anticoagulant ... #Monoclonal #Differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Others: • Lupus ... lupus erythematosus ... to exclude are infections ... #rheumatology # ... classification
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... - HIV infection ... anemia - Persistent ... neurofibromatosis, vasculitis ... #Diagnosis #Differential
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... • Autoimmune diseases ... lupus erythematosus ... diagnosis #types #classification ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: ... permanent alopecia Differential ... fibromyalgia) • Infections ... lymphopenia, low PLT • Anemia
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
- SLE (systemic ... lupus erythematosus ... Congenital heart disease ... other severe infections ... - Vasculitis
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
leukocytosis, in vitro hemolysis ... : syßtemic lupus ... antiphospholipid syndrome ... #Hyperkalemia #Differential ... High #Potassium #Classification
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