Causes of Purpura or Easy Bruising in Children
Platelet count reduced, i.e. thrombocytopenia
- Increased platelet destruction or consumption
- Immune
- ITP (immune thrombocytopenia)
- SLE (systemic lupus erythematosus)
- Alloimmune neonatal thrombocytopenia
- Non-immune
- Haemolytic uraemic syndrome
- Thrombotic thrombocytopenic purpura
- DIC (disseminated intravascular coagulation)
- Congenital heart disease
- Giant haemangiomas (Kasabach—Merritt syndrome)
- Hypersplenism
- Impaired platelet production
- Congenital
- Fanconi anaemia
- Wiskott—Aldrich syndrome
- Bernard—Soulier syndrome
- Acquired
- Aplastic anaemia
- Marrow infiltration (e.g. leukaemia)
- Drug-induced
Platelet count normal
- Platelet dysfunction
- Congenital - Rare disorders, e.g. Glanzmann thromboasthenia
- Acquired - Uraemia, cardiopulmonary bypass
Vascular disorders
- Congenital
- Acquired
- Meningococcal and other severe infections
- Vasculitis, e.g. Henoch—Schönlein purpura, SLE
- Scurvy
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