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hematology anemia bruising cryoglobulinemia cryoglobulins dermatologic dermatology erythematosus extravascular gpa granulomatosis hemolysis monoclonal oncology paraproteinemias pediatrics peds phtn polyangiitis pulmonary
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... agglutin disease ... #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease ... Agglutinin Syndrome ... Diagnosis: • hemolytic ... #agglutinin #disease ... #hematology #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... often causes arthritis ... differential #diagnosis ... #rheumatology # ... classification
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... - HIV infection ... neurofibromatosis, vasculitis ... #Diagnosis #Differential ... #Causes
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... • IgA vasculitis ... • Vasculitis ... #rheumatology # ... vasculitis
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... • Pauci-immune vasculitis ... Diagnosis: Vasculitis ... Granulomatous vasculitis ... • Necrotising vasculitis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... • Coombs (-) hemolytic ... anemia due to cold ... #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... vasculitis, rheumatoid ... fibromyalgia) • Infections ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
SLE (systemic lupus ... (disseminated intravascular ... Congenital heart disease ... - Vasculitis ... #differential #
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