8 results
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... : • ANCA-associated ... Serositis Labs: • ANA ... • (-) ANA + (+ ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
(Granulomatous disease ... : • Behçet Syndrome ... atherosclerotic disease ... LFT • ESR • ANA ... , and SLE) • Urinalysis
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
with disease activity ... searched for when ANA ... with auto-immune diseases ... #diagnosis #rheumatology ... #table #ANA
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Asia • HLA-B51 association ... syndrome (Clinical ... #Syndrome #diagnosis ... #management #signs ... #symptoms #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... • Autoimmune diseases ... Types II and III ... DDX: • ANCA (Antineutrophil ... erythematosus (
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Systemic rheumatic diseases ... disease, drug reactions ... most important diseases ... (GRANULOMATOUS DISEASE ... • Behcet syndrome
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
Antibodies targeting ... had more severe disease ... three days #AntiNXP2DM ... #AntiNXP2 #Dermatomyositis ... #diagnosis #management
Relapsing Polychondritis

What is it?
Recurrent inflammation of the cartilage in the body (Autoimmune disorder)

Who?
• Most frequently: 40
immunologically mediated diseases ... cases such as: • SLE ... disease • Infections ... Nonspecific ↑ ESR, CRP, ANA ... #diagnosis #management