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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
(Granulomatous disease ... atherosclerotic disease ... LFT • ESR • ANA ... ) pattern: antibodies ... , and SLE) • Urinalysis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... : • ANCA-associated ... diseases (i.e. ... Serositis Labs: • ANA ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Summary Cryoglobulins ... Syndrome: • Clinical ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... erythematosus (
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... searched for when ANA ... with auto-immune diseases ... #diagnosis #rheumatology ... #table #ANA
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... : Chronic disease ... #sle #comparison ... #table #rheumatology ... #diagnosis #management