8 results
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Gravis, Graves' Disease ... complexes • Ex: Systemic ... Lupus Erythematosus ... #Types #Classification ... #Diagnosis #Definitions
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Butterfly rash, Vasculitis ... #Lupus #SLE #systemic ... #erythematosus ... #signs #symptoms
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... photosensitivity, inflammatory ... Classification: ... lupus erythematosus ... #Systemic #Lupus
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
during hemolytic disease ... lupus erythematosus ... - Contact dermatitis ... #Pathophysiology ... #Allergy #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Syndrome: - Ocular inflammatory ... as systemic lupus ... Symptoms (Sx) in ... , and SLE) • Urinalysis ... #rheumatology #classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
reaction, Haemolytic disease ... glomerulonephritis, Systemic ... lupus erythematosus ... #table #classification ... #comparison
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
as SLE, atherosclerotic ... Symptoms (SX) in ... ischemia • Skin: Erythematous ... • Progressive symptoms ... syndrome: Ocular inflammatory
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
lupus erythematosus ... (SLE), Sjögren’ ... ANCA-associated vasculitis ... cell lymphoma Pathophysiology ... symptoms Histopathological