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differential classification ana antineutrophil antinuclear bee cryoglobulinemia cryoglobulins dermatology erythematosus inflammatory lcv leukocytoclastic neurology polychondritis prs pulmonary relapsing renal sjogrens
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... • Sjögren syndrome ... Vasculitis: • ... Renal-limited vasculitis ... #antibodies #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... Vasculitis: + MPO-ANCA ... Mucocutaneous lymph node syndrome ... : • Behçet Syndrome ... • Cogan Syndrome
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... Inflammatory causes ... • Cogan syndrome ... • Systemic lupus ... vasculitides •
Vancomycin induced Leukocytoclastic Vasculitis (LCV) of the Hand 70 M vertebral osteomyelitis on vancomycin and cefepime for
Leukocytoclastic Vasculitis ... antiphospholipid syndrome ... Churg-Strauss syndrome ... HSP, urticarial vasculitis ... #LCV #Hand #skinrash
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... Cryoglobulinemia Syndrome ... cryoglobulinemia syndrome ... Cryoglobulinemia Syndrome ... 20% Sjögren's syndrome
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Mucocutaneous lymph node syndrome ... often causes arthritis ... • Behcet syndrome ... • Cogan syndrome ... #Rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal Syndromes ... vasculitis (AAV ... Pulmonary Renal Syndromes ... palpable purpura 2/2 vasculitis ... : ANCA antibody,
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
vasculitis, rheumatoid ... lymphoma • Evans' syndrome ... Shrinking lung syndrome ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... SLE • Mikulicz syndrome ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... Diagnosis #Management
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
common • Sjogren’s syndrome ... • MAGIC syndrome ... • Vexus syndrome ... Nodosa, GCA, Sweet syndrome ... #diagnosis #management
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