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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitis and Vasculitides ... • EGPA: - Eosinophilia ... often causes arthritis ... C-ANCA) pattern: antibodies ... #rheumatology #
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... • IgA vasculitis ... Hypersensitivity vasculitis ... • Vasculitis ... #vasculitis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... • Sjögren syndrome ... ANCA-Associated Vasculitis ... Renal-limited vasculitis ... #diagnosis #rheumatology
Vancomycin induced Leukocytoclastic Vasculitis (LCV) of the Hand
70 M vertebral osteomyelitis on vancomycin and cefepime for
Leukocytoclastic Vasculitis ... Diagnosis? ... HSP, urticarial vasculitis ... Leukocytoclastic #Vasculitis ... #LCV #Hand #skinrash
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... to cold IgG • Lupus ... Episodic angioedema+eosinophilia ... #Differential #Diagnosis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis Framework ... Polyangiitis): • Eosinophilia ... often causes arthritis ... / ANCA + MPO) Cryoglobulinemic ... #Rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
salivary ducts Clinical ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... #Rheumatology # ... Diagnosis #Management