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differential clinical erythematosus lesions manifestations monoclonal nonpalpable oncology palpable paraproteinemias pathology purpura semiology signs skin systemic types vasculitides
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus ... #classification ... #rheumatology #
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Connective tissue disease ... (10%) : SLE +++ ... #Vasculitis #dermpath ... #dermatology #semiology ... signs #lesions #diagnosis
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
- Differential Diagnosis ... : CTD: SLE, RA related ... Urticarial/LCV) - Cryoglobulinemic ... : • Behcet Disease ... #dermatology #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... Pigmented Purpuric Dermatosis ... /HSP • Cryoglobulinemia ... #hematology #rheumatology ... #nonpalpable #dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
such as systemic lupus ... , and SLE) • Urinalysis ... Serologies for Cryoglobulins ... #rheumatology # ... classification
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
gangrenosum • Cutaneous ... Scleromyxedema (Dermato-neuro ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: ... Differential Diagnosis ... Non-autoimmune rheumatologic ... #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... , such as SLE, atherosclerotic ... / ANCA + MPO) Cryoglobulinemic ... - interstitial keratitis ... #Rheumatology
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