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differential classification erythematosus oncology signs symptoms systemic behcet cryoglobulinemia management nonpalpable pain palpable paraproteinemias rashes sweet types vasculitides
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Skin ulcers ... • Autoimmune diseases ... ) • Cutaneous ... (e.g. systemic lupus ... classification #rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
lesions • Discoid lupus ... Sarcoidosis #dermatology ... #joint #pain #skin ... #differential #diagnosis ... #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
: CTD: SLE, RA related ... Petechiae, Palpable purpura ... : • Behcet Disease ... • Cogan syndrome ... #dermatology #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Diagnosis Framework ... purple, hemorrhagic skin ... Dermatosis: Schamberg ... #hematology #rheumatology ... #nonpalpable #dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
vesicular eruption - Joints ... such as systemic lupus ... , and SLE) • Urinalysis ... Serologies for Cryoglobulins ... #rheumatology #
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... , Purpura, Urticaria ... Demyelinating syndromes ... #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
gangrenosum • Cutaneous ... Scleromyxedema (CNS+GI+CVS+joints ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... Differential Diagnosis ... Arthritis: • Joint ... #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... , such as SLE, atherosclerotic ... vesicular eruption • Joints ... , joint & gut involvement ... #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
) • Cutaneous Lesions ... lesions, palpable purpura ... Oral aphthae : SLE ... : monoclonal TNF-aIpha ... signs #symptoms #rheumatology
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