10 results
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Gravis, Graves' Disease ... Type III Hypersensitivity ... Lupus Erythematosus ... #Types #Classification ... #Diagnosis #Definitions
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... complement - 50 ... Evolution: Chronic disease ... #lupus #Systemic
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Chain deposition disease ... Lupus Erythematosus ... Hypocomplementemia #Low ... #Complement #CHAMPS ... #Mnemonic #diagnosis
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
during hemolytic disease ... lupus erythematosus ... - Contact dermatitis ... #Types #Classification ... #Reactions #Table
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Decade Skin Disease ... diseases (i.e. ... #Systemic #Lupus ... #Diagnosis #Rheumatology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
, Haemolytic disease ... glomerulonephritis, Systemic ... lupus erythematosus ... Examples: Contact dermatitis ... #reactions #types
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
months to years) Systemic ... Lupus Erythematosus ... Evolution: Chronic disease ... #table #rheumatology ... #diagnosis #management
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... factor level • Low ... lupus erythematosus ... #types #classification ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
(Granulomatous disease ... diseases, such ... as systemic lupus ... atherosclerotic disease ... most important diseases
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Studies in Rheumatic Diseases ... lupus erythematosus ... exclude inflammatory disease ... connective-tissue disease ... #Rheumatic #Disease