8 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... connective tissue disease ... 90% • Anti-GBM disease ... #antibodies #diagnosis ... diseases
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
infection • Lyme disease ... Palpable purpura ... syndromeVasculitis ... Sarcoidosis #dermatology ... #diagnosis #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... - Bone marrow disease ... Disease Others ... Diagnosis #hematology ... #dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
• Kawasaki Disease ... Diagnosis: Systemic ... rheumatic diseases ... , and SLE) • Urinalysis ... differential #diagnosis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Clinical triad of Palpable ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... cytoplasmic antibody ... lupus erythematosus
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... diseases, such ... ) • Palpable purpura ... #Differential #Diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Diagnosis: • ANCA-associated ... tissue disease ... and CNS • Headache ... #Systemic #Lupus
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Systemic disease ... multiforme-like lesions, palpable ... purpura, Pathergy ... ) Differential Diagnosis ... Nonsurgical abdominal pain