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rheumatology classification differential allergy ana antibodies erythematosus hypersensitivity patterns reactions syndrome vasculitis allergic cryoglobulinemia cryoglobulins definitions dermatology imdamnsharp laboratory management
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
tissue disease ... Juvenile Idiopathic Arthritis ... (SLE), Systemic ... Kumfer @AnnKumfer #Antinuclear ... #rheumatology #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... (SLE), Systemic ... : Lupus (SLE), Systemic ... Kumfer @AnnKumfer #Antinuclear ... #rheumatology #diagnosis
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Discoid Rash A Antinuclear ... cytopenias) A Arthritis ... R Renal Disease ... #IMDAMNSHARP #sle ... #systemic #lupus
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Gravis, Graves' Disease ... complexes • Ex: Systemic ... Lupus Erythematosus ... , Reactive Arthritis ... Classification #Diagnosis
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
during hemolytic disease ... glomerulonephritis, rheumatoid arthritis ... , and systemic lupus ... - Contact dermatitis ... Pathophysiology #Allergy #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Differential Diagnosis ... • Type-I Interferonopathies ... #Systemic #Lupus ... Erythematosus #Diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • Autoimmune diseases ... : - 10% SLE or ... Labs/Diagnosis: ... lupus erythematosus
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
febrile neutrophilic dermatosis ... disease. ... such as certain types ... ’s syndrome - Lupus ... Sweet #Syndrome #diagnosis
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
affected joint • Systemic ... lupus erythematosus ... (SLE) - Antinuclear ... Tests for All Types ... (to support a diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... inflammation Others: • Lupus ... lesions-interstitial keratitis ... as systemic lupus ... vasculitis, and SLE
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