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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Mucocutaneous lymph node syndrome ... : • Behçet Syndrome ... • Cogan Syndrome ... : - Ocular inflammatory ... such as systemic lupus
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Syndrome Definition ... ANCA-positive vasculitis ... ANCA-negative vasculitis ... IgA-associated vasculitis ... diagnosis #nephrology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
BEE Syndromes - ... • Systemic lupus ... ANCA-associated vasculitides ... #neurology #inflammatory ... #differential #
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... affects the skin, neurologic ... cognitive impairment, neurologic ... • Behcet syndrome ... • Cogan syndrome
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
disease, Leprosy • Inflammatory ... , Vasculitis, Sjogren's ... , Lupus, Sarcoidosis ... Paraprotein-associated (POEMS syndrome ... diagnosis #causes #neurology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Syndromes - OnePager ... Autoimmune ANCA vasculitis ... Renal Syndromes ... palpable purpura 2/2 vasculitis ... #Syndromes #differential
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
Reconstitution Inflammatory ... Syndrome (IRIS) ... Worsening of previous neurologic ... Meningitis • Include: vasculitis ... #TB #neurology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... : Vasculitis • ... Paraneoplastic syndrome ... Lambert-Eaton - Isaacs' syndrome ... #Diagnosis #neurology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
capillary leak syndrome ... et diutinum Neurologic ... Hyperviscosity syndrome ... Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis