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diagnosis classification allergy differential hypersensitivity types rheumatology table algorithm allergic causes comparison definitions dermatology druginduced pathophysiology pharmacology risk sle systemic
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
• Contact dermatitis ... Bullous systemic lupus ... erythematous ... • Phototoxic drug ... Vesiculobullous #SkinRash
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Penicillin-induced drug ... • Ex: Systemic Lupus ... Erythematosus, ... Syndrome, Contact Dermatitis ... (ie. reaction to
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
hypersensitivity reactions ... Food allergies, Drug ... glomerulonephritis, Systemic lupus ... erythematosus Type ... Examples: Contact dermatitis
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Lupus Erythematosus ... for 1 year of treatment ... SLE #Systemic #Lupus ... #Erythematosus ... #medications #drugs
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
allergies, and drug ... , and systemic lupus ... erythematosus ... - Contact dermatitis ... Allergy #Diagnosis #Reactions
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... ischemia - Skin: erythematous ... such as systemic lupus ... erythematosus, ... reactions, and
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