6 results
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
• Contact dermatitis ... • Bullous systemic ... lupus erythematous ... • Phototoxic drug ... Vesiculobullous #SkinRash
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Penicillin-induced drug ... complexes • Ex: Systemic ... Lupus Erythematosus ... Syndrome, Contact Dermatitis ... (ie. reaction to
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
hypersensitivity reactions ... Food allergies, Drug ... glomerulonephritis, Systemic ... lupus erythematosus ... Examples: Contact dermatitis
Drug Induced Systemic Lupus Erythematosus
> 100 drugs have been associated with drug-induced SLE
High risk (>5%):
 •
Drug Induced Systemic ... Lupus Erythematosus ... for 1 year of treatment ... #Lupus #Erythematosus ... #medications #drugs
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- Local and systemic ... allergies, and drug ... lupus erythematosus ... - Contact dermatitis ... Allergy #Diagnosis #Reactions
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
inflammation Others: • Lupus ... Vasculitis • Drug ... ischemia - Skin: erythematous ... lupus erythematosus ... reactions, and