11 results
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Penicillin-induced drug ... complexes • Ex: Systemic ... Lupus Erythematosus ... Syndrome, Contact Dermatitis ... (ie. reaction to
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
• Contact dermatitis ... • Bullous systemic ... lupus erythematous ... • Phototoxic drug ... Vesiculobullous #SkinRash
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Food allergies, Drug ... glomerulonephritis, Systemic ... lupus erythematosus ... Examples: Contact dermatitis ... #reactions #types
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... allergies, and drug ... lupus erythematosus ... - Contact dermatitis ... Allergy #Diagnosis #Reactions
Drug Induced Systemic Lupus Erythematosus
> 100 drugs have been associated with drug-induced SLE
High risk (>5%):
 •
Drug Induced Systemic ... Lupus Erythematosus ... for 1 year of treatment ... #Lupus #Erythematosus ... #medications #drugs
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... Kikuchi disease • Type-I ... lupus erythematosus ... #Lupus #Erythematosus
Causes of Acute Pericarditis:

Infectious;

Viral: 
Adenovirus 
Coxsackie virus A and B 
Echovirus 
Epstein-Barr virus 
Hepatitis 
Human immunodeficiency
- related Medication ... induced (select drugs ... Sjögren syndrome Systemic ... lupus erythematosus ... #Pericarditis #Differential
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitides - Differential ... inflammation Others: • Lupus ... ischemia - Skin: erythematous ... lupus erythematosus ... reactions, and
Erythemas Summarized
Erythema ab igne
 • A dermatosis that results from repeated exposure to heat (fires, heating
Erythema ab igne • A dermatosis ... form of delayed-type ... hypersensitivity ... presenting with erythematous ... malignancies, and drugs
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
atherosclerotic disease, drug ... reactions, and ... ischemia • Skin: Erythematous ... inflammation Hypersensitivity ... viral infection, drug