12 results
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
lupus erythematosus ... lupus erythematosus ... • Nucleolar: Diffuse ... lupus erythematosus ... #differential
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Diagnosis Algorithm ... Lupus Erythematosus ... • Rheumatoid Arthritis ... • Acne • Allergy
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
complexes • Ex: Systemic ... Lupus Erythematosus ... , Reactive Arthritis ... Syndrome, Contact Dermatitis ... Classification #Diagnosis
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
Diagnosis Algorithm ... • Contact dermatitis ... • Bullous systemic ... lupus erythematous ... Vesiculobullous #SkinRash
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
lupus erythematosus ... lupus erythematosus ... • Nucleolar: Diffuse ... lupus erythematosus ... #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Suspect: Clinical ... permanent alopecia Differential ... lupus erythematosus ... #Lupus #Erythematosus
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
glomerulonephritis, rheumatoid arthritis ... , and systemic lupus ... erythematosus ... - Contact dermatitis ... #Diagnosis #Reactions
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Definition: Diffuse ... Diagnosis for Pulmonary ... lupus erythematosus ... , Rheumatoid arthritis ... , Systemic sclerosis
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
Allopecia - Differential ... Diagnosis Framework ... erythematosus, ... Traction alopecia Diffuse ... Vitamin D levels Systemic
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Diagnosis Framework ... inflammation Others: • Lupus ... ischemia - Skin: erythematous ... Diagnosis: Systemic ... lupus erythematosus