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hematology agglutinin algorithm cold conjugated disease elevated extravascular hemolysis hodgkins hypertension intravascular jaundice laboratory lactate ldh lymphomas lymphoproliferative management nonhodgkin
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... e.g. lupus, CLL, lymphoma ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
(LDH) - Differential ... Diagnosis Framework ... Legionnaires disease • Pulmonary ... paralyses CNS Disorders ... Malignancy: • Lymphomas
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Disorders - Differential ... lymphadenopathy more diffuse ... #Classification ... #pathophysiology ... #Hematology #Diagnosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
or lymphoid malignancy ... Diagnosis: • hemolytic ... Elevated lactate dehydrogenase ... younger pts) Differential ... #anemia #hematology
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... Schistosomiasis - Chronic hemolytic ... anemia - Persistent ... #Diagnosis #Differential ... #Causes
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... nodosum • Immune hemolytic ... Immunohistochemical studies (to differentiate ... #diagnosis #classification ... #hematology #oncology
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
anemias, hemolytic ... reactions, hematoma, pulmonary ... , sarcoidosis, lymphomas ... #diagnosis #conjugated ... #unconjugated #differential
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