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differential oncology algorithm eosinophils hypereosinophilia treatment vasculitis allergy anemia aplastic cardiology classification disorders eoe eosinophil gastroenteritis hypereosinophilic leukemia leukostasis lysis
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
Clinically Relevant HES ... #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis ... #management #algorithm
Hypereosinophilia Syndrome (HES) - Diagnosis and Management Definition: An absolute eosinophil count (AEC) greater than 1500 and
(HES) - Diagnosis ... Secondary Causes ... #HES #eosinophilia ... #diagnosis #hematology ... #eosinophils
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Hypereosinophilic Syndrome ... - Chronic Eosinophilic ... #Causes #hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... of eosinophilia ... organ-specific signs ... #Differential #diagnosis ... #hematology #eosinophilia
Eosinophilic Gastroenteritis: Treatment Options Based on Severity of the Disease Mild: • Trial of PPI • Trial
Eosinophilic Gastroenteritis ... : • Hematology ... • Additional diagnostic ... scan #EoE #Eosinophilic ... #gastroenterology
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
- Differential Diagnosis ... ESRD & CAD • Eosinophilic ... cell activation syndrome ... #Differential #Diagnosis ... #hematology #allergy
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... - Hepatitis, eosinophilic ... Anemia #oncology #hematology ... #diagnosis #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
capillary leak syndrome ... Episodic angioedema+eosinophilia ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... high WBC count cause ... WBC >100k, + lab signs ... #TLS #diagnosis ... #management #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... • (Peripheral eosinophilia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
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