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differential oncology eosinophils hypereosinophilia leukemia treatment algorithm allergy anemia aplastic causes chronic eoe gastroenteritis hemophagocytic hlh hypereosinophilic lymphocytic lymphohistiocytosis monoclonal
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
Clinically Relevant HES ... #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis ... #management #algorithm
Hypereosinophilia Syndrome (HES) - Diagnosis and Management Definition: An absolute eosinophil count (AEC) greater than 1500 and
(HES) - Diagnosis ... with blood eosinophilia ... #HES #eosinophilia ... #diagnosis #hematology ... #eosinophils
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Hypereosinophilic Syndrome ... - Chronic Eosinophilic ... #Causes #hematology
Eosinophilic Gastroenteritis: Treatment Options Based on Severity of the Disease Mild: • Trial of PPI • Trial
Eosinophilic Gastroenteritis ... : • Hematology ... • Additional diagnostic ... scan #EoE #Eosinophilic ... #gastroenterology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• (Peripheral eosinophilia ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Agent Orange or Hep ... Physical Exam/Signs ... Diagnosis: • ... • Richter’s Syndrome ... workup #oncology #hematology
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
- Differential Diagnosis ... ESRD & CAD • Eosinophilic ... Causes: • Mast cell ... activation syndrome ... #hematology #allergy
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Episodic angioedema+eosinophilia ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... - Hepatitis, eosinophilic ... Anemia #oncology #hematology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... : HLH signs and ... Low or absent NK cell ... #management #treatment ... #hematology
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