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diagnosis management algorithm disease eosinophils hes agglutinin allergy anemia cold cutaneous disorders eosinophil gap globulin hemolytic hypereosinophilic oncology paraproteinemias pathergy
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
Secondary Hypereosinophilic ... Syndrome • Clinically ... suspect underlying hematologic ... #Hematology #eosinophilia ... #eosinophils #diagnosis
Hypereosinophilia Syndrome (HES) - Diagnosis and Management Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia ... than 1500 and clinical ... Secondary Causes ... Malignancy - Immunologic ... #hematology #differential
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
/hypereosinophilia ... • Screen for secondary ... symptoms (eg, skin ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
- Differential ... Leukocytoclastic Vasculitis Secondary ... Vasculitis: • Behcet ... Disease • Cogan syndrome ... #dermatology #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... thrombosis+Pulm HTN+skin ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... syndrome (Clinical ... disease) Differential ... refractory disease : monoclonal ... signs #symptoms #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
AIHA Primary Secondary ... Cold Agglutinin Syndrome ... Viral Infection Clinical ... younger pts) Differential ... hemolytic #anemia #hematology
Pathergy Summary Overview What is pathergy? Pathergy is an exaggerated skin injury occurring after minor trauma such as
following: • Behcet ... interferon-alpha • Atypical eosinophilic ... Pathergy #diagnosis #differential ... #allergy #immunology ... #dermatology #skin
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... changes (POEMS syndrome ... Liver disease: Cirrhosis ... gastric tumors • Hematology ... #diagnosis #hematology
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