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diagnosis management treatment betadglucan comparison fungal galactomannan infectiousdiseases latenttb rheumatology tb testing tuberculosis abscess aids aspergillus biomarkers causes challenges erythematosus
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
affecting the lungs ... lymph nodes Risk ... • Lymphoma • Lung ... • Progressive lung ... Inhibitor: • Risk
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
affecting the lungs ... lymph nodes Risk ... • Lymphoma • Lung ... • Progressive lung ... Inhibitor: • Risk
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Food products Risk ... Illnesses: • Pulmonary ... complicate MAC pulmonary ... infiltrates NTM Pulmonary ... #differential #
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
polymicrobial infection ... pneumonia • DM risk ... Abscess Differential ... #Abscess #pulmonary ... #differential #
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... in HIV - Differential ... Pneumonia: • Risk ... #AIDS #pulmonary ... #differential #
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
invasive fungal infection ... surfaces - Infections ... useful in high risk ... BAL GM does not differentiate ... admin of mold-active
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... fibromyalgia) • Infections ... extremity edema, active ... Thrombosis highest risk ... and leukemia • Lung
Fluid Responsiveness and Fluid Tolerance Testing - OnePager Summary Fluid resuscitation can be beneficial when required or
vasopressors and lower risk ... Pulmonary Artery ... via cold saline injection ... • PULMONARY A ... testing #diagnosis #criticalcare
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
surfaces, Albumin, Infections ... useful in high risk ... in BAL does not differentiate ... concurrent admin mold-active ... result in + as long
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
effusion, INC risk ... Malignancy Risk ... MALT Lymphoma • Lung ... lubricants • Pharmacologic ... muscarinic agonists • Active
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