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hematology ana antibodies antinuclear apml behcet classification differentiation disease erythematosus gitelman gravis hodgkins hypokalemia lupus lymphoma monoclonal myasthenia nephrology neurology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Syndrome Diagnosis ... gland) biopsy • Ocular ... #Syndrome #Rheumatology ... #Diagnosis #Management
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence ... Syndrome (SS), ... Syndrome, Myositis ... ANA #patterns #rheumatology ... #diagnosis #differential
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Autoimmune: thyroid, Sjogren ... Ocular- 50%: Ptosis ... life-threatening Differential ... myasthenia Diagnosis ... #management #neurology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
ulceration • Ocular ... Behcet disease) Differential ... Diagnosis: • Genital ... #diagnosis #management ... signs #symptoms #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... initiation • Differential ... Differentiation #Syndrome ... #management #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
capillary leak syndrome ... Hypergammaglobulinemic macular ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematous, macular ... permanent alopecia Differential ... dermatomyositis, Sjogren ... Non-autoimmune rheumatologic ... #Rheumatology
Syphilis - Clinical Manifestations and Treatment 1) Primary Syphilis • Direct lesion contact during sex is responsible
lesion contact during ... Albuminuria, nephrotic syndrome ... ulcerated • MSK ... Syphilis #stages #diagnosis ... #management #Treatment
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
lymph node biopsy (diagnostic ... Immunohistochemical studies (to differentiate ... Hodgkins #lymphoma #diagnosis ... classification #hematology ... #oncology #management
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
hypokalemic salt-losing ... ratio 0.5%) Differential ... Autoimmune disease (Sjögren ... #diagnosis #nephrology ... #management #pathophysiology
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