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diagnosis ebm differential visualabstract management causes algorithm infections hiv treatment clinical pharmacology nejm hivaids infectiousdiseases pocus cardiology neurology opportunistic nephrology
Differential Diagnosis for Generalized Lymphadenopathy Viral • HIV • EBV • CMV • HBV • Dengue • Rubella
Lymphadenopathy Viral • HIV ... • EBV • CMV ... • HBV • Dengue
Infection-Related Cancers Viruses: • HPV - Cervical, anogenital, head and neck, skin cancer • HTLV-1 - Adult
Cancers Viruses: • HPV ... T-cell Leukemia • HIV ... cell carcinoma • HBV ... carcinoma • HHV ... Kaposi's sarcoma • EBV
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
borrelia, Rubeola, HBV ... Coxsackie, CMV, EBV ... , HIV, HTLVI, Hantavirus
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Viral infections (HAV ... , HBV, HCV, HEV, ... EBV, CMV), Alcohol-related
Hepatitis B Virus Serology and Interpretation HBsAg - Anti-HBs - Anti-HBc - HBeAg - Anti-HBe - Acute
- Anti-HBe - ... replication - Inactive HBV ... carrier state (low HBV ... replication (high HBV ... #HepatitisB #HBV
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
• Infectious: HAV ... , HBV, HCV, HEV, ... EBV, HSV, CMV,
SCORTCH Congenital Infections Mnemonic S - Syphilis C - CMV O - Other R - Rubella T - Toxoplasmosis C - Chickenpox
Varicella) H - HSV ... , HIV, HTLV-1, HBV ... , HCV #SCORTCH
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
detectable, high HBV ... undetectable, low HBV ... detectable, high HBV ... Indicated: • HBV ... Pregnancy with HBV
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
• Infectious: HAV ... , HCV, HEV, EBV, ... HSV, CMV • Neoplasm
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
pts with chronic HBV ... phases of chronic HBV ... Quant HBV DNA. ... the reservoir of HBV ... Chronic #HepatitisB #HBV
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