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diagnosis management neurology rheumatology differential classification acidosis activation cardiology cerebritis chf chronic cns criticalcare cryoglobulinemia cryoglobulins dermatology dili druginduced elevation
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Rheumatoid Arthritis ... • Drug Abuse (e.g ... Chronic Fatigue Syndrome
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
of information (e.g ... non-essential drug/HDS treatments ... for alternative causes ... vascular disorder (e.g ... #hepatology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
, rheumatoid arthritis ... Clinical Picture ... dystrophy - Brain stem ... Serologic and EMG ... Clinical DX: -
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... underlying disease (eg ... • Infection (eg ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... not be subtle e.g ... E.g. 80 yo ESR cutoff ... vision changes, etc ... Treatment of GCA
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
nonerosive inflammatory arthritis ... Rule out other causes ... and lower jaw Treatment ... antiinflammatory properties e.g ... Tetracyclines etc
Recurrent Polymorphic VT/Torsades de Pointes - Management Algorithm Drugs that prolong QT interval: • Class 1a (quinidine,
Pointes - Management Algorithm ... Syndrome Electrolyte ... Hypocalcemia (rarely) Treatment ... 1b (lidocaine)- case ... TDP #Management #Algorithm
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... Lumbar Puncture, EEG ... Treatment:
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... : • Clinical triad ... arthralgia, and arthritis ... tissue disorder (e.g
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Prevalence: 1-2 cases ... Clinical Manifestations ... unit activity on EMG ... of diazepam • EMG ... EMG Studies:
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