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diagnosis hematology differential macrocytosis aafp atlas cobalamin deficiency elevatedmcv folate folicacid homocysteine mds mentzerindex microcytic microscopy mma morphology myelodysplasia myelodysplastic
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
(sometimes) Macrocytic ... RBC: Vitamin B12 ... Chemotherapy (e.g ... Unstable hemoglobin disorders ... #BloodCell #RBC
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Red cell distribution ... (EPO), iron or B12 ... (BM) ablative disorders ... of substrate (e.g ... #Workup #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Drugs Oval Macrocytes ... Increased Requirement (e.g ... • Small Bowel Disorder ... #Causes #Hematology
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
Algorithm for the ... evaluation of macrocytic ... (RBC = red blood ... the most likely cause ... #Workup #AAFP
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... proportion of the red ... that involves disorders ... These causes could ... Red cell distribution
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... dysfunction, and/or disorders ... : • Worsening macrocytic ... anemia, yellow ... Deficiency #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... common cytopenia: Macrocytic ... Nutritional: vitamin B12 ... Workup: • Complete
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Diagnosis and Management ... Prevalence: 1-2 cases ... and pernicious anemia ... antibody that works ... limb or joint disorders
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