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diagnosis hematology differential elevatedmcv macrocytosis management microcytic atlas b12 cobalamin deficiency dili druginduced eosinophil eosinophilia hepatology injury liver mds microscopy
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... 95 (or 100) is macrocytic ... (BM) ablative disorders ... of substrate (e.g ... #Workup #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology Microcytic ... (sometimes) Macrocytic ... Chemotherapy (e.g ... Unstable hemoglobin disorders ... Diseases #Red #BloodCell
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Drugs Oval Macrocytes ... Increased Requirement (e.g ... • Small Bowel Disorder ... #Causes #Hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Differential Diagnosis Algorithm ... HgbE, HgbC, etc. ... #Microcytic #Anemia ... Differential #Diagnosis #Algorithm
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Testing Algorithm ... evaluation or workup ... glucocorticoid treatment ... signs or symptoms (eg
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... for alternative causes ... Hepatic vascular disorder ... Injury #Diagnosis #Algorithm
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... dysfunction, and/or disorders ... : • Worsening macrocytic ... anemia, yellow ... Check for IF ab Treatment
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... common cytopenia: Macrocytic ... Neutropenia • Platelet Disorders ... Workup: • Complete
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Prevalence: 1-2 cases ... and pernicious anemia ... antibody that works ... limb or joint disorders ... Person Syndrome Treatment
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