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management rheumatology causes differential erythematosus sle systemic acidosis activation algorithm arteritis arthritis cerebritis chronic classification cns dermatology disease elevation extravascular
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g ... deficiencies (e.g ... #hematology #anemia
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Lumbar Puncture, EEG ... Treatment: ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... • Infection (eg ... with leukopenia, anemia ... Treatment: • Corticosteroids ... #Diagnosis #Management
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... Pulmonary Disease Neurologic ... • Drug Abuse (e.g ... Chronic Fatigue Syndrome
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... lymphopenia, low PLT • Anemia
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
and pernicious anemia ... unit activity on EMG ... of diazepam • EMG ... EMG Studies: ... #neurology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
with systemic, neurologic ... not be subtle e.g ... E.g. 80 yo ESR cutoff ... systemic complaints- anemia ... Treatment of GCA
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
and lower jaw Treatment ... antiinflammatory properties e.g ... Tetracyclines etc ... diagnosis #management ... #Dermatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... the presence of anemia ... inflammatory disease (e.g ... Chemistry profile (e.g ... (to support a diagnosis
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
by excretion (e.g ... its metabolism (e.g ... hypoxemia/Sepsis etc ... - Compartment syndrome ... 30mmHg) - Severe anemia
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