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diagnosis management differential oncology algorithm anemia aplastic arteritis blood chronic cll comparison cryofibrinogenemia dili disorders eosinophil eosinophilia gap gca giantcell
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... glucocorticoid treatment ... signs or symptoms (eg ... , skin or esophageal ... Differential #diagnosis #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
toxic aetiology: Skin ... non-essential drug/HDS treatments ... for alternative causes ... hepatitis #DILI #DrugInduced ... Diagnosis #Algorithm #hepatology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rule out other causes ... and lower jaw Treatment ... Tetracyclines etc ... #Rheumatology # ... diagnosis #management #Dermatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... Lupusreference #druginduced ... sle #comparison #table ... #rheumatology #
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... organ damage • Treatment ... Low calcium • Treatment ... unless worrisome EKG ... diagnosis #management #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cryoglobulin (CG ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... that are caused ... Workup: • Complete ... #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Headaches • Pale skin ... and petechiae Causes ... aplastic anemia Treatment ... Anemia #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... microglobulin Treatment ... • Richter’s Syndrome ... Leukemia #diagnosis #workup ... #oncology #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
hypertension and/or drug treatment ... Constitutional disorders, eg ... neutropenia, Kostmann syndrome ... Chediak-Higashi syndrome ... #hematology
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