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diagnosis hepatology algorithm workup causes hepatitis infectiousdiseases rheumatology abnormal acidosis agglutinin aih alkaline alp arthritis autoimmune bandemia cellulitis chemistry classification
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential ... disturbance (obstructed liver ... Highest • Bone • Liver ... biliary Cholangitis (PBC ... #Differential #
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects, Drugs, Liver ... Defects: Sickle cell anemia ... #Diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Autoimmune hepatitis, PBC ... stone, Malignancy, PBC ... Bilirubin - +/- elevation ... Enzyme Elevation
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... disease: > 2 ... chemistry #diagnosis #differential ... #LFTs #RValue #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... disease, decrease ... changes), high MCV anemia ... gastric bypass), LFT ... (liver disease)
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
magnitude of enzyme elevation ... body mass index; FBC ... disease; T2DM, ... #LFTs #Abnormal ... #Differential #
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... • Autoimmune diseases ... appreciate the value ... #differential # ... #CBC #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... If the value is ... Mild-to-moderate elevation ... count and differential ... Diagnosis #Workup #Hematology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
from subclinical disease ... to acute liver ... hepatocellular pattern of liver ... reported (eg AIH-PBC ... (rare) - IgG Elevation
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... • Symptoms of anemia ... Blood smear - RBC ... younger pts) Differential ... #hematology #diagnosis
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