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diagnosis algorithm causes cholangitis gastroenterology hematology injury mass referral workup alkaline alp biliary calling chemistry cirrhosis consultation disorders drug elevation
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #hepatology
Liver Mass Differential Diagnosis Solid: • Benign: Hepatic Hemangioma, Focal nodular hyperplasia, Hepatocellular adenoma, Regenerative nodules •
Liver Mass Differential ... disease, Biliary ... Cystadenocarcinoma, Primary ... #Mass #Differential ... #Diagnosis #hepatology
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
Primer - Guide ... - Vitals - LFTs ... GTT, indirect bili ... disease work up ... Calling #Referral #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Venoocclusive disease ... • Iatrogenic: DILI ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
Liver Mass - Differential Diagnosis Algorithm Cystic: • Benign - Simple: Simple
Liver Mass - Differential ... Disease, Caroli's ... Malignant - primary ... - HCC, CCA, HB ... Algorithm #Causes #Hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... disturbance (obstructed liver ... Highest • Bone • Liver ... - Drugs - Primary ... Diagnosis #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... disease: > 2 ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Cholestatic disease ... • Others #LFTs ... #Hepatology #LiverEnzymes
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... cholestasis → Cirrhosis/Liver ... or higher • Liver ... bile ducts Differential ... diagnosis #workup #hepatology
Non-alcoholic fatty liver disease algorithm. For those patients with NAFLD or liver disease of unknown aetiology,
fibrosis score with values ... markers such as ELF ... 4, fibrosis-4; HCC ... algorithm #Referral #Management ... #Hepatology
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