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diagnosis causes hematology lactate liver acidosis acute algorithm chemistry classification dehydrogenase elevated elevation failure hemolysis hepatitis interpretation laboratory lactic lfts
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
) - Differential ... muscle, liver, and kidney ... • Hemolytic Anemias ... - Prosthetic valves ... Dehydrogenase #Elevated #differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... cardiac muscle, kidneys ... • LDH: Heart, ... #hepatitis #differential ... diagnosis #algorithm #hepatology
Causes of Acute Kidney Injury ( AKI ) - Prerenal, Renal, and Postrenal PRE-RENAL Impaired perfusion: •
Injury ( AKI ) ... • Inflammatory disease ... Urethral stricture/valves ... Postrenal #Failure #Differential ... #Nephrology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell anemia ... #Diagnosis #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... of cholestatic disease ... • LDH: Heart, ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... hallmark for the disease ... If the value is ... dehydrogenase (LDH ... WBC count and differential
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Aldolase ↑ • LDH ... nephrotoxicity to kidney ... of underlying disease ... causes #treatment #nephrology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... to bolus these values ... presentations and disease ... liver or renal injury ... 30mmHg) - Severe anemia
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