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diagnosis management classification oncology acidosis acquired agglutinin arteritis causes cell cold community disease elevation gap gca giantcell globulin hemolysis hemolytic
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell anemia ... Haptoglobin ↓ - Lactate ... #Diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
If the value is ... elevation Serum lactate ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... www.ncbi.nlm.nih.gov/pmc ... to bolus these values ... before beginning treatment ... 30mmHg) - Severe anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... Hyperbilirubinemia • Elevated lactate ... younger pts) Differential ... #hematology #diagnosis
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Bands > 15% • Uremia ... negative predictive value ... procalcitonin level Treatment ... cultures/nasal PCR ... Diagnosis #Management #treatment
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
or sed rate): Value ... very remarkable w/differential ... GCA, but normal values ... systemic complaints- anemia ... Treatment of GCA
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... Hodgkin Lymphoma Treatment ... classification #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... #ProteinGap #differential ... #diagnosis #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
• No CRAB - no anemia ... lytic lesions • Lactate ... Bone marrow Treatment ... Oncology #Diagnosis #Workup ... #Hematology
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