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hematology management treatment acidosis causes criticalcare infectiousdiseases acquired agglutinin algorithm cap chronic classification cold community disease elevation foamed gastroenterology hemolysis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Acidosis - Differential ... e.g., uptake by cells ... to bolus these values ... 30mmHg) - Severe anemia ... #Elevation #Differential
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Lactic Acidosis ... - Differential Diagnosis ... Shock, Severe Anemia ... Beta-Agonists, ↑ work ... #Acidosis #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Hyperbilirubinemia • Elevated lactate ... malignancies - B-cell ... younger pts) Differential ... Disorders Such As ... sensitize red blood cells
Visceral Leishmaniasis - Diagnosis and Management Summary Species: Leishmania donovani, Leishmania infantum, Leishmania chagasi Where: South Asia, East
Middle East and Latin ... Evades innate and cell-mediated ... Lymphadenopathy, Malaise, Abdominal ... Lymphohistiocytosis • Anemia ... 20 mg/kg/d IV/IM
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... elevation Serum lactate ... WBC count and differential ... #Workup #Hematology
Chronic Abdominal Pain Causes - Differential Diagnosis Framework Many patients with chronic abdominal pain have had prior
Pain Causes - Differential ... dysfunction • PSC ... malignancy • Lactase ... appendages • FMF ... Chronic #Causes #Differential
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Pneumonia (CAP) - Diagnosis ... negative predictive value ... Inpatient Pneumonia: β-Lactam ... Inpatient Pneumonia: β-Lactam ... macrolide or β-lactam
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... • No CRAB - no anemia ... lesions • Lactate ... myeloma Diagnostic ... #Workup #Hematology
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
hormones that work ... But we also have Lactic ... Acidosis as well ... convert Pyruvate to Lactate ... #diagnosis #differential
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