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hematology acidosis causes classification cold disease elevation hemolysis hemolytic oncology plasmacytoma solitary typea typeb
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... Hyperbilirubinemia • Elevated lactate ... younger pts) Differential ... Disorders Such As
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Acidosis - Differential ... e.g., uptake by cells ... to bolus these values ... 30mmHg) - Severe anemia ... #Elevation #Differential
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... • No CRAB - no anemia ... lesions • Lactate ... myeloma Diagnostic ... #Workup #Hematology
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