8 results
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Acidosis - Differential ... e.g., uptake by cells ... to bolus these values ... 30mmHg) - Severe anemia ... and can act as
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Hyperbilirubinemia • Elevated lactate ... malignancies - B-cell ... younger pts) Differential ... Disorders Such As ... sensitize red blood cells
Visceral Leishmaniasis - Diagnosis and Management Summary
Species: Leishmania donovani, Leishmania infantum, Leishmania chagasi
Where: South Asia, East
Middle East and Latin ... Evades innate and cell-mediated ... Lymphadenopathy, Malaise, Abdominal ... Lymphohistiocytosis • Anemia ... 20 mg/kg/d IV/IM
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... elevation Serum lactate ... WBC count and differential ... #Workup #Hematology
Community Acquired Pneumonia (CAP) - Diagnosis and Management

Pneumonia Signs/Symptoms:
 • Confusion/disorientation (LR + 1.9)
 • Cough
) - Diagnosis and ... negative predictive value ... Inpatient Pneumonia: β-Lactam ... Inpatient Pneumonia: β-Lactam ... macrolide or β-lactam
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
can present as ... Diagnosis? ... • No CRAB - no anemia ... lesions • Lactate ... #Workup #Hematology
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
patients such as ... Advanced HIV (CD4 cell ... enzymes, diarrhea, abdominal ... Bone Marrow - Anemia ... NTM #Infections #differential